[Update:Capcom has confirmed that it will arrive on PC, PS4, and Xbox One in spring 2019.]
Capcom showed off Devil May Cry 5 at Microsoft's E3 conference. Throwing shade at DmC ("fans have been asking for a true sequel ever since Devil May Cry 4"), this game looks all crazy and high-tec and absolutely bonkers.
I don't know if that is exactly what Devil May Cry was all about, but it certainly isn't the last game. It also seems that Nero is the protagonist this time, which would follow in line from 4.